Technology

Moving cells with sound

The core technology of AcouSort is acoustofluidics. Here, we combine acoustics and microfluidics to separate and trap cells and particles in acoustic fields. These techniques can perform almost any operation that is normally achieved through centrifugation in the biology or clinical lab – faster, automated and with more gentle sample handling.

Acoustic separation

To separate cells, the sample is flushed through a microchannel, typically half a millimeter wide. An ultrasonic standing wave is generated across the channel, creating a pressure field. The acoustic forces will move cells and particles denser and less compressible than the surrounding medium to the pressure node in the center of the channel.

This allows for a range of different operations – cells can be washed, concentrated or moved from one medium to another. Different types of cells can be separated from each other based on differences in size, density or compressibility. All of this can be performed using our technology, either in the AcouWash standalone platform or in customized OEM solutions.

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Acoustic trapping

In acoustic trapping, cells and particles are not only moved by the ultrasound – they are captured and held against the fluid flow. This allows for cells to be enriched and removed from their medium. With the use of larger seed particles, the technology also enables isolation of submicron particles such as extracellular vesicles or bacteria. The technology is available in the form of an AcouTrap benchtop system, or as a customized OEM solution.

Do not hesitate to contact us to discuss if our products, technologies or OEM solutions can be used for your applications.